Understanding Acute Sarcopenia

University of Birmingham168 enrolled

Overview

This study aims to characterise acute changes in muscle mass, strength, physical performance in hospitalised older adults. We will assess the impact of these changes upon physical function at three month follow-up, and assess for the impact of clinical and immune-endocrine factors upon these changes.

Study Design Time-limited cohort study involving serial measurements of Bilateral Anterior Thigh Thickness (BATT) using ultrasound, handgrip strength, physical performance, and physical function measured using the Patient Reported Outcome Measures Information System (PROMIS®). We aim to fully characterise changes in these patients, and will perform a comprehensive evaluation of clinical factors including nutrition and physical activity, and measure immune-endocrine markers of inflammation. Study Participants Elective colorectal surgery, emergency abdominal surgery, and medical patients aged 70 years and older Planned Size of recruitment target 56 elective colorectal patients, 56 emergency abdominal surgery patients, and 56 medical patients with acute infections Follow up duration 3 months Primary research question Does acute change in quadriceps muscle thickness, handgrip strength and/or physical performance within one week of hospitalisation predict change in patient reported physical function at three months?

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

168

Conditions

Sarcopenia

Interventions

Colorectal surgery procedurePROCEDURE

Elective admission for colorectal surgery

Emergency abdominal surgeryPROCEDURE

Emergency admission necessitating emergency surgery

AntibioticsDRUG

Treatment for infection and reason for admission

Eligibility

Sex: ALLMin age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: ELECTIVE COHORT * Aged 70 years or older at time of recruitment * Expected to undergo an elective major colorectal surgery procedure EMERGENCY SURGERY COHORT * Aged 70 years or older at time of recruitment * Emergency admission * Expected to undergo emergency abdominal procedure during admission, or emergency abdominal procedure performed within previous 48 hours MEDICAL COHORT * Aged 70 years or older at time of recruitment * Emergency admission for acute bacterial infection or presumed acute bacterial infection Exclusion Criteria: ELECTIVE COHORT * Unable to provide written informed consent at time of recruitment * Unable to understand verbal English * Life expectancy less than 30 days EMERGENCY SURGERY COHORT * Unable to provide written informed consent at time of recruitment and no consultee available * Unable to understand verbal English * Life expectancy less than 30 days MEDICAL COHORT * Unable to provide written informed consent at time of recruitment and no consultee available * Unable to understand verbal English * Life expectancy less than 30 days

Locations (1)

Queen Elizabeth Hospital Birmingham

Birmingham, West Midlands, United Kingdom

RECRUITING

Outcomes

Primary Outcomes

Physical function

Change in physical function at three months as measured by the T score derived from the Patient Reported Outcome Measures Information System (PROMIS®) - Item Bank v. 2.0, Physical Function, Short Form 10b. This is a patient-reported outcome measure of physical function. Raw scores are collected out of a maximum of 50; minimum of 10. These are converted to T scores, which are used for analysis (mean 50, SD 10; range 13.8 - 61.3). Higher scores are representative of better physical function.

Time frame: Three months

Secondary Outcomes

Short Physical Performance Battery (SPPB)

Change in Short Physical Performance Battery (SPPB) score at (elective cohort)

Time frame: Three months

Bilateral Anterior Thigh Thickness (BATT)

Change in BATT (elective and emergency cohorts)

Time frame: Three months

Handgrip strength

Change in handgrip strength (elective and emergency cohorts)

Time frame: Three months

Acute changes during hospitalisation - gait speed

Change in gait speed within one week of hospitalisation (elective and emergency cohorts)

Time frame: One week

Acute changes during hospitalisation - BATT

Change in BATT within one week of hospitalisation (elective and emergency cohorts)

Time frame: One week

Acute changes during hospitalisation - handgrip strength

Change in handgrip strength within one week of hospitalisation (elective and emergency cohorts)

Central Contacts

Carly Welch, MBChB

CONTACT

+44 (0)121 414 3344 c.welch@bham.ac.uk

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.