High-flow Nasal Cannula Flow Rates, Severe Bronchiolitis

Ali Yurtseven168 enrolled

Overview

Objective: The investigators aimed to compare the heated humidified high-ﬂow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency department. Study design: The investigators performed a study in which all patients were allocated to receive these two flow rates. The primary outcome was admitted as treatment failure, which was defined as a clinical escalation in respiratory status. Secondary outcomes covered a decrease of respiratory rate (RR), heart rate (HR), the clinical respiratory score (CRS), rise of peripheral capillary oxygen saturation (SpO2) and rates of weaning, intubation and intensive care unit (ICU) admission. Keywords: Bronchiolitis, Emergency department, High-flow nasal cannula, Flow rate

Study Type

OBSERVATIONAL

Enrollment

168

Conditions

Non-invasive Ventilation Pediatric Pulmonary Disease

Interventions

Heated humidiﬁed high-flow nasal cannula

Eligibility

Sex: ALLMin age: 1 DayMax age: 2 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of severe bronchiolitis * Must be less than 24 months * Must have presented to the emergency department Exclusion Criteria: * Immediate invasive ventilation and/or intensive care unit admission * Congenital heart disease, * Chronic lung disease * Neuromuscular disease * Netabolic disease * Craniofacial anomalies * Immunocompromised * Bacterial pneumonia * Pneumothorax * Nasal trauma

Outcomes

Primary Outcomes

Treatment failure rate

We compared the treatment failure between the 1-L/kg/min flow rate with 2-L/kg/min rate in patients with severe bronchiolitis

Time frame: Within 24 hours