Effects of Dietary Supplements on Sarcopenic Elders

Far Eastern Memorial Hospital85 enrolled

Overview

Sarcopenia is defined as a syndrome characterized by decline of skeletal muscle mass and strength or an alteration in physical function. Although some studies showed nutritional supplementation alone might have health benefits for older sarcopenic patients, the results were inconsistent and remain controversial. The objective of this study was to evaluate if a sufficient protein diet including supplements with leucine-enriched whey protein and vitamin D can lead to better improvement than sufficient dietary protein alone in maintaining muscle mass and strength among sarcopenic elders.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Sarcopenia

Interventions

Protison with High Protein 51(Original Flavor)DIETARY_SUPPLEMENT

Contents of each supplement sachet has a calorie of 88 kcal, 12.8 g protein( including 8.5 g whey protein concentrate), 1.2 g leucine, 7.3 g carbohydrates, 0.8 g fat and 120 IU vitamin D per serving. This supplement was added 200 ml water and stirred well, then drank before meal.

Eligibility

Sex: ALLMin age: 65 YearsMax age: 95 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Older adults (≥ 65 years) * Subject has lower appendicular muscle mass index (AMMI) (\<7 kg/m\^2 in men; \<5.7 kg/m\^2 in women) using Bioelectrical impedance analysis (BIA, TANITA BC-418®, Tokyo, Japan) * Subject has lower handgrip strength (\<26 kg in men; \<18 kg in women) using dynamometer (CAMRY®, Zhongshan, Guangdong) or slowly gait speed (\<1 m/s) Exclusion Criteria: * Subject's life expectancy was shorter than 6 months * Nursing home resident * Subject has the history of kidney failure * Subject has the history of liver failure * Subject has the history of diabetes mellitus * Subject has resistance exercise habit.

Locations (1)

Far Eastern Memorial Hospital

New Taipei City, Banciao Dist, Taiwan

Outcomes

Primary Outcomes

AMMI(appendicular muscle mass index)

Bioelectrical impedance analysis was used to obtain appendicular muscle mass (AMM) and height. The unit of AMM and height were represented as kilogram and meter respectively. AMMI were calculated as AMM/height\^2 (kg/m\^2).

Time frame: Change measures (baseline and 4 weeks, baseline and 12 weeks)

Handgrip strength

Hand dynamometer was used to measure handgrip strength. Subject was asked to sit in an upright position with the upper arm forming a virtually 90 degree angle with the forearm. Three consecutive measurements of grip strength obtained from both hands were recorded and average of the highest value was calculated as the maximum grip strength. The unit of handgrip strength was represented as kilogram.

Time frame: Change measures (baseline and 4 weeks, baseline and 12 weeks)

Gait speed

Asking the subjects to perform a 5-meter walk at their usual pace and measure how much second they could complete this distance, then the unit of gait speed was represented as m/s.

Time frame: Change measures (baseline and 4 weeks, baseline and 12 weeks)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.