The purpose of this study is to investigate the prevalence of soft markers which will be identified during a second trimester ultrasound. Secondary aims were to estimate the association between the soft markers and trisomies 13, 18 and 21 as well as the effect on the number of invasive tests will be performed.
Study Type
OBSERVATIONAL
Enrollment
100
A detailed anomaly scan to detect soft markers at 16 to 24 weeks pregnancy
Fetal karyotyping after birth to confirm chromosomal anomaly diagnosed clinically
Cairo University
Cairo, Egypt
To study the association between soft markers identified at second trimester ultrasound and aneuploidy.
fetal soft markers detection which include the following: * choroid plexus cyst. * Mild ventriculomegaly. * Enlarged cistern magna. * Nasal bone hypoplasia. * Increased nuchal fold. * Echogenic cardiac focus. * Single umbilical artery. * Pyelectasis. * Echogenic bowl. * Short femur. * Short humerus. All data will be collected and statistics will be done for the correlation between one or more soft markers with structural anomalies and its relation with aneuploidy.
Time frame: 1 year
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