Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.

Assisting Nature180 enrolled

Overview

A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in oocyte donors.

A randomized prospective study of the use of single dose of the long acting GnRH antagonist Degarelix for ovarian stimulation cycle in oocyte donors: Ovarian stimulation started on cycle Day2 with gonadotropins 175-300 IU and either GnRH antagonist single dose Degarelix or multidose GnRH antagonist Ganirelix initiated on Day6 of the stimulation cycle. Agonist triggering was used in both groups for oocyte maturation. Blastocyst formation rate and Live Birth Rates were estimated for both groups.

Study Type

OBSERVATIONAL

Enrollment

180

Conditions

Infertility Premature Ovarian Failure

Interventions

live birth rateDIAGNOSTIC_TEST

The blastulation rate and live birth rate according to the protocol of COS

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 34 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 20-34 years; * body mass index (BMI) 18-29kg/m2; * regular menstrual cycle of 26-35 days, * AMH levels age appropriate (≥2.3 ng/ml) * early follicular- phase serum concentration of FSH within normal limits (1-12 IU/l). Exclusion Criteria: * women with diabetes and other metabolic disease * women with hereditary genetic diseases; * women with heart disease, QT prolongation,heart failure * elevated liver enzymes, liver failure, hepatitis * women with inflammatory or autoimmune disease * abnormal karyotype; * endometriosis stage III/IV; * history of recurrent miscarriage; * severe OHSS in a previous stimulation cycle or any contraindication for the use of gonadotrophins.

Locations (1)

Assisting Nature

Thessaloniki, Greece

RECRUITING

Outcomes

Primary Outcomes

Live birth rate according to stimulation protocol

Time frame: Up to 38 weeks after embryo transfer

Secondary Outcomes

Blastulation rate according to stimulation protocol

Time frame: Up to 6 days post oocyte retrieval

Central Contacts

Evaggelos Papanikolaou, MD,PhD

CONTACT

00302310424294 drvagpapanikolaou@yahoo.gr

Data from ClinicalTrials.gov

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