Intrapleural Bupivacaine for Ipsilateral Shoulder Pain After Thoracotomy

McGill University Health Centre/Research Institute of the McGill University Health Centre42 enrolled

Overview

While thoracic epidural could control incisional pain after thoracotomy, an excruciating ipsilateral shoulder pain happens post thoracotomy and could affect up to 85% of thoracotomy patients. It is often difficult to manage and relatively resistant to opioids. The investigators postulate that in the presence of a functioning thoracic epidural, intrapleural bupivacaine administered through the chest tube could be effective in reducing post thoracotomy ipsilateral shoulder pain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Post Thoracic Surgery

Interventions

Bupivacaine-epinephrineDRUG

See previous description

Normal salineDRUG

See previous descreption

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and Female, between 18 and 80 years, ASA 1-3, Scheduled for open thoracotomy Exclusion Criteria: * ASA \>3, morbid obesity BMI\>40, Previous cardiac or ipsilateral thoracic surgery, Renal or hepatic failure, anemia, allergy to local anesthetics, contraindications to receive regional anesthesia, patient refusal, reiteration due to complication

Locations (1)

Montreal General Hospital

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Change in VAS scores

ISP visual analogue scale scores before intrapleural block and at 30 min, 4 hours and 24 hours

Time frame: from 0 hour to 24 hour

Secondary Outcomes

Forced Vital Capacity

Time frame: from 0 hour to 48 hour

Total epidural infusion

Time frame: from 0 hour to 48 hour

Co-analgesia consumption

Time frame: from 0 hour to 48 hour

Data from ClinicalTrials.gov

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