The increase in life expectancy of the world population is associated with a higher incidence of diseases, leading to functional incapacity and dependence in old age. Aging is usually accompanied by progressive loss of muscle mass, muscular strength and functional capacity, possibly exacerbated by inactivity and low protein and energy consumption of elderly individuals. However, the response to strength training, as well as the daily recommendation of protein and other factors related to sarcopenia in this population seem not to be well understood. Objective: To evaluate the effect of protein intake and resistance training on body composition, muscle strength and functional capacity in the elderly. METHODS: A randomized placebo-controlled clinical trial will be conducted with 38 elderly people, ≥ 60 years old, sedentary, and body mass index between 22 and 30 kg / m2. All those who agree to participate will be randomized into two groups (intervention or placebo) and will undergo an initial assessment consisting of food consumption analysis through the application of the three-day food record, assessment of muscle thickness of the thigh and arm by muscle ultrasonography, evaluation of body composition by dual energy X-ray absorptiometry (DEXA), dynamic maximal strength (1RM) test of knee extension and elbow flexion, peak torque test of knee extension, functional capacity tests and quality of life questionnaire (SF-36). The elderly will participate in resistance training for 12 weeks, two session per week. The intervention group will be supplemented with whey protein isolate (2x / day - 20g for breakfast and 20g for dinner) and the placebo group will receive maltodextrin (2x / day - 20g for breakfast and 20g for dinner). All outcomes will be assessed before and after the 12-week resistance training period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
38
Whey protein (2x / day - 20g for breakfast and 20g for dinner).
Maltodextrin (2x / day - 20g for breakfast and 20g for dinner).
Federal University of Health Sciences
Porto Alegre, Rio Grande do Sul, Brazil
Densitometry by dual energy X-ray absorptiometry (DEXA) change from baseline.
Measure body composition, such as total fat mass (kg), total fat-free mass (kg), and fat-free mass in the thigh (kg) will be assessed using Dual Energy X-Ray Absorption Densitometry (HXD) (Hologic Discovery W, USA).
Time frame: This measure will be performed before and after the intervention (12 weeks resistance training and supplementation).
Ultrasonography change from baseline.
The evaluation of muscle thickness of the quadriceps femoris muscles, as well as the brachial and brachial biceps will be done by means of an image obtained using the Ulio XG ultrasound device (Toshiba, Japan).
Time frame: This measure will be performed before and after the intervention (12 weeks resistance training and supplementation).
Muscular strength (peak of torque) change from baseline.
The torque production rate will be calculated from the torque-time curves obtained during a maximal voluntary isometric contraction of knee extension performed on an isokinetic dynamometer (Cybex, Ronkonkoma, USA).
Time frame: This measure will be performed before and after the intervention (12 weeks resistance training and supplementation).
Muscular strength (1-RM) change from baseline.
The 1-RM tests (1 maximum repetition test) of knee extension and elbow flexion will be performed in an extensor chair and Scott bench, respectively (Mark Können Gym, China), bilaterally.
Time frame: This measure will be performed before and after the intervention (12 weeks resistance training and supplementation).
Functional capacity (sit and stand up test) change from baseline.
The number of sit and stand movements in the chair will be evaluated in 30 seconds.
Time frame: This measure will be performed before and after the intervention (12-week resistance training and supplementation).
Functional capacity (timed up and go test) change from baseline.
The task will be to walk a three-meter course, get around a cone, go back and sit in the chair. The result will be expressed in seconds.
Time frame: This measure will be performed before and after the intervention (12-week resistance training and supplementation).
Functional capacity (stair climbing test) change from baseline.
Task to climb a flight of stairs at a comfortable speed and without the aid of the handrail and the time will be measured in seconds.
Time frame: This measure will be performed before and after the intervention (12-week resistance training and supplementation).
Protein intake (dietary record) baseline.
Time frame: To evaluate the food consumption will be used the dietary record of three days.
Protein intake (24-hour food recall).
Time frame: To verify possible changes in dietary intake over the 12 weeks of intervention, a 24-hour food recall will be applied on the fourth and eighth week and immediately after the last training session.
Diet Quality Index.
Time frame: To evaluate the quality of the diet will be used the Healthy Eating Index (HEI) that assigns scores to the diet according to the adequacy of the food and nutrients intake, based on the 24 hour reminders previously applied.
Quality of life (SF-36) change from baseline.
Time frame: This measure will be performed before and after the intervention (12-week resistance training and supplementation). The SF-36 (Medical Outcomes Study 36) questionnaire will be used to evaluate the quality of life of the elderly.
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