The purpose of the study is to test if using these living donor-specific pre-transplant resources would lead to a better and faster recovery post-transplant.
Donor safety and outcomes are the chief concerns of programs performing living donor liver and kidney transplantation. The protection of donors from physical and emotional harm has been a fundamental principle in living donor liver and kidney donation from the beginning. The safety of living donor hepatectomy and nephrectomy has been established. The risks associated with the donation have been deemed acceptable by the transplant community. The investigators would like to move beyond the safety of the operation and address the most important post-operative issues that potentially cause donors physical and emotional stress: these include pain control, appropriate nutrition for optimal liver regeneration and physical/functional recovery, fatigue, time to return to normal physical and work activity, and difficulties coping with recovery and any possible complications. The goal of conducting this study is to create a program of pre- and post-operative interventions to enhance recovery so that patients can return to their normal quality of life as soon as possible. Currently there is no literature on programs to enhance living donor care and recovery. This study will be conducted to determine if interventions during the pre-operative (a minimum of four weeks in an exercise program), intra-operative (anesthesia), and post-operative (pain management) stages have an effect on liver and kidney donor patients' quality of life and return to baseline functional status.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
21
Behavioral, nutritional, physical and opioid-reduction pain medication
Baylor University Medical Center
Dallas, Texas, United States
RAND SF-36 questionnaires
Pre-operative emotional stress
Time frame: From day of enrollment in the study (at least 4 weeks before surgery) up to 1 day prior to hepatectomy.
Level of pain experienced daily
level of pain per numerical rating pain scale (scale 0-10) with 0 being no pain and 10 being severe pain.
Time frame: From day of admission into ICU (post-hepatectomy) up to day of hospital discharge (4-14 days post-hepatectomy)
Duration in ICU
Duration in ICU post-hepatectomy
Time frame: From day admission into ICU up to day of discharge to hospital floor or 14 days post hepatectomy, whichever came first.
Opioid usage
Number of participants that require using opioid medication to treat abdominal and incisional pain post hepatectomy, medication strength and frequency of use.
Time frame: From day of hospital discharge (post-hepatectomy) up to 1 year post hepatectomy.
RAND SF-36 questionnaires
Post-operative emotional stress
Time frame: From month 1 to month 12 post transplantation.
Duration to return of daily activities
Duration to return of daily activities
Time frame: From day of hospital discharge to 1 year follow up.
Incidence of Post-operative hospital re-admissions
Number of post-operative hospital re-admissions
Time frame: From post-transplant discharge to 1 year follow-up
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