Effects of Ivabradine on Residual Myocardial Ischemia After PCI

Inclusion Criteria: * coronary artery disease with chronic stable angina for more than three months (Canadian Cardiovascular Society-CCS-class I-III); * percutaneous revascularization with stent implantation at least one; * signs/symptoms of residual ischemia; sinus rhythm; HR ≥ 70 bpm at rest; * ability to perform an echocardiogram stress test with the tilting bicycle stress test (BST); * good acoustic window; * age ≥ 18 years. Exclusion Criteria: * drugs intolerance or hypersensitivity * EF ≤ 40 % * NYHA class III to IV; * CCS IV * atrial fibrillation or flutter * presence of a pacemaker or implantable defibrillator * II or III degree AV block * HR ≤ 70 bpm at rest or sick sinus syndrome * any condition that could interfere with the ability to exercise stress test like Wolff- Parkinson-White syndrome, left bundle branch block, left ventricular hypertrophy; * rate-corrected QT interval (QTc) greater than 500 ms or the use of drugs that prolong the QTc interval * symptomatic hypotension or uncontrolled hypertension (systolic blood pressure at rest ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg) * severe liver disease and severe renal impairment (creatinine clearance ≤ 30 ml/min) * electrolyte disorders * uncontrolled thyroid disease * pregnancy.