Meniscal tissue has very limited intrinsic properties in terms of repair, given the low mitotic activity of chondrocytes and poor vascularization. Nevertheless, its capacity for regeneration, in vivo and in vitro, can be stimulated by the contribution of growth factors, as has been widely described in the medical and scientific literature. Platelet Enhanced Plasma (PRP) is an autologous biological product (that is, derived from the patient's blood) containing a growth factor concentrate. The contribution of these growth factors stimulates cartilage repair by stimulating neovascularization, collagen synthesis and activation of chondrocytes. Intra-articular injection PRP is an autologous biological product, now used in daily practice for the treatment of early osteoarthritic lesions. The hypothesis of this work is that the injection of PRP in contact with LMD(Degenerative Meniscal Lesions) will improve the clinical symptomatology of our patients compared to reference treatment (intra-auricular injection of corticosteroids).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
intra-articular injection
intra-articular injection
A CONTROL RMI at 1 year follow-up.
Assistance Publique Hopitaux de Marseille
Marseille, France
Control by Magnetic Resonance Imaging (MIR)
To evaluate the evolution of the LMD compared to pretherapeutic images.
Time frame: 12 Months
self-completed questionnaire EVA score
EVA (analogical visual scale)
Time frame: 12 Months
self-completed questionnaire SF36
SF36 (The Short Form (36) Health Survey)
Time frame: 12 Months
self-completed questionnaire KOOS score
KOOS (Knee Injury and Osteoarthritis Outcome Score)
Time frame: 12 Months
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