Muscle wasting has a multifactorial origin, including decreased physical activity, malnutrition, loss of post-incident muscle recovery abilities, and decreased ability to regenerate muscle. Among the strategies tested to improve the production of proteins and thus muscle is the supplementation of whey proteins. However this strategy does not seem sufficient and optimal to avoid muscle wasting and it must be complemented by a complementary action. Muscle protein degradation also occurs during the nocturnal fasting periods to provide amino acids for energy purposes and to produce glucose, essential for vital organs. The preservation of the benefit of whey intake during meals could therefore be optimized by reducing the use of muscle proteins for energy purposes during the night.
In this study, three arms will be studied for 3 months: 1 control group, 1 group with whey supplementation at lunch, and 1 group with whey supplementation at lunch and an energy bolus before bedtime. Actions include weight and body composition monitoring, nutritional status and muscle function, as well as mechanistic.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
6
In addition to their normal meal, patients will eat 30g of whey protein every lunch during 90 days.
In addition to their normal meal, patients will eat 30g of whey protein every lunch during 90 days and eat 60g of carbohydrates 2h after every diner during 90 days.
EHPAD Cité des Aînés
Saint-Etienne, France
EHPAD La Cerisaie
Saint-Etienne, France
EHPAD Le Soleil
Saint-Etienne, France
Appendicular lean body mass (gramme)
Comparison appendicular lean body mass between the day of inclusion and 90 days after. It is measuring by Dual Energy X-ray Absorptiometry (DEXA).
Time frame: Days 0 and 90
total body composition
Correlation between Dual Energy X-ray Absorptiometry (DEXA) results and bioelectrical impedance analysis results to determine total body composition.
Time frame: Days 0, 45 and 90
Plasma albumin level (g/l)
blood sample.
Time frame: Days 0, 45 and 90
Frailty screening tool
Determination of fragility status. 3 status : Dependent, Fragile, Robust
Time frame: Days 0 and 90
Mini Nutritional Assessment score
Determine nutritional status. Score : 0-30
Time frame: Days 0 and 90
Inflammatory status
Analysis of inflammatory status by blood sample results. C-reactive protein (CRP), Interleukin 6 (IL-6), Tumor necrosis factor (TNFα), monocyte chemoattractant protein 1 (MCP1)
Time frame: Days 0, 45 and 90
Hand Grip test (N)
Analysis of muscle function tests.
Time frame: Days 0 and 90
6 minutes walk test (m)
Analysis of muscle function tests.
Time frame: Days 0 and 90
Maximal voluntary contraction of quadriceps (N)
Analysis of muscle function tests.
Time frame: Days 0 and 90
Get up-and-go test (s)
Analysis of muscle function tests.
Time frame: Days 0 and 90
Profiles of the differential expression of potentials biomarkers
Analysis of profiles of the differential expression of potentials biomarkers by results of blood sample with heparin, urine sample and white blood cells.
Time frame: Days 0, 45 and 90
microbiota
Analysis of microbiota by stool sample results.
Time frame: Days 0 and 90
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