For cancers, such as mesothelioma, that spread to the lining of the stomach, detecting the cancer is very difficult with CT or MRI scans. Researchers at the University of Chicago want to find out if the new experimental MRI and ultrasound imaging techniques do a better job of detecting these cancers. Researchers will use new MRI and ultrasound techniques to see if it can find evidence of cancer that has spread to the lining of the abdomen, and right now these new techniques are only used for research.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
26
The first 5 patients will undergo HR-MRI scans using different sequence parameters. Results in these patients will then be assessed along with standard CT Imaging to determine which sequences appear to best identify peritoneal disease. The optimal HR-MRI sequences will then be used for the next 19 patients in the Testing phase to formally define their performance compared to standard imaging.
Standard CT scans will be performed for preoperative imaging in all patients.
Ultrasound Elastography will be performed using an FDA-Approved diagnostic GE ultrasound scanner
University Of Chicago Medicine Comprehensive Cancer Center
Chicago, Illinois, United States
Higher Sensitivity for detection using New High Resolution Contrast Enhanced MRI Imaging Sequences compared to standard MRI
New HR-MRI sequences will demonstrate greater sensitivity than standard MRI for detecting peritoneal metastases.
Time frame: 60 Days
Higher sensitivity for detection of peritoneal metastatic disease using Ultrasound Elastography compared to standard MRI
Ultrasound Elastography will demonstrate greater sensitivity than standard MRI for detecting peritoneal metastases.
Time frame: 60 Days
The performance of diffusion-weighted MRI in detecting peritoneal disease in patients with malignant peritoneal mesothelioma
Use diffusion-weighted MRI in detecting the per-region sensitivity in patients with MPM
Time frame: 60 days
Test high-definition small-voxel MRI imaging sequences for detection of peritoneal disease in MPM
To test HR-MRI sequences for detection of peritoneal disease in MPM focusing on the right hemidiaphragmatic and pelvic spaces
Time frame: 60 days
Perform Ultrasound Elastography in peritoneal mesothelioma to determine optimal strain ratios
Ultrasound Elastography to determine optimal strain ratios to maximize sensitivity in PM patients
Time frame: 60 days
Perform Ultrasound Elastography in peritoneal mesothelioma to determine elasticity scores
Ultrasound Elastography to determine elasticity scores to maximize sensitivity in PM patients
Time frame: 60 days
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