Different Application Rates of Crisaborole Ointment 2% in Adults With Mild to Moderate Atopic Dermatitis

Inclusion Criteria: * Confirmed diagnosis of active atopic dermatitis (AD) with at least 6 month history prior to screening and that has been clinically stable for 1 month. * Has four application areas of 3 cm in diameter with a TSS of ≥5 and TAA of moderate at Day 1. The application areas must not be located on the face, scalp, axillae, groin, genitals, hands, and feet. The application areas should be ≥1 cm apart. Exclusion Criteria: * Subject is a female who is breastfeeding, pregnant, or who is planning to become pregnant during the study. * Subject has clinically infected AD. * Subject has a Fitzpatrick's Skin Phototype ≥5. * Subject is known to have immune deficiency or is immunocompromised. * Subject has a history of cancer or lymphoproliferative disease within 5 years prior to Day 1. Subjects with successfully treated nonmetastatic cutaneous squamous cell or basal cell carcinoma and/or successfully treated localized carcinoma in situ of the cervix are not to be excluded. * Subject had a major surgery within 8 weeks prior to Day 1 or has a major surgery planned during the study. * Subject has any clinically significant medical condition that would, in the opinion of the investigator, put the subject at undue risk or interfere with interpretation of study results. * Subject has a known history of chronic infectious disease (eg, hepatitis B, hepatitis C, or infection with human immunodeficiency virus). * Subject with a known lack of efficacy to crisaborole. * Subject has a known or suspected allergy to crisaborole, including any non-medicinal ingredient, or component of the container. * Subject has a known history of clinically significant drug or alcohol abuse in the last year prior to Day 1.