Preoperative Portal and Splanchnic Flow Measurement Using MRI

Seoul National University Hospital12 enrolled

Overview

This study aims to assess the alteration of portal and splanchnic flow using MRI after liver transplantation in patients with splenomegaly or splenic varix.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Liver Cirrhoses

Interventions

Liver MRIDIAGNOSTIC_TEST

Liver MRI including 4D flow sequence is performed twice in liver transplantation recipients, before and 1 month-after transplantation. In donor candidates, liver MRI including 4D flow sequence is performed twice in 1-3 weeks to assess repeatability of the technique.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * older than 18 years * And signed informed consent * And planned either a) liver transplantation as a recipient; or b) liver transplantation as a donor Exclusion Criteria: * any absolute/relative contraindication of contrast-enhanced MRI

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Portal flow

portal flow measured with MRI (4D flow sequence)

Time frame: in a month after 2nd MRI

Secondary Outcomes

SMV flow

superior mesenteric vein (SMV) flow measured with MRI (4D flow sequence)

Time frame: in a month after 2nd MRI

Splenic vein flow

splenic vein flow measured with MRI (4D flow sequence)

Time frame: in a month after 2nd MRI

splenic varix flow

splenic varix flow measured with MRI (4D flow sequence) only in liver recipients

Time frame: in a month after 2nd MRI

Data from ClinicalTrials.gov

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