Impact of CYP3A4*1G Polymorphism on Non-analgesic Effects of Fentanyl in Chinese Han Patients

Inclusion Criteria: * American Society of Anesthesiologists GradeⅠ-II,Patients undergo elective surgery for benign Reproductive diseases (including laparoscopic ovarian cyst removal, laparoscopic tubal ligation, laparoscopic tubal drainage, laparoscopic salpingoplasty, etc.) or breast disease. * Aged 18-45 years * Body Mass Index 18-25kg/m2,body weight 40-65 kilograms * Agreed to participate the research Exclusion Criteria: * Difficult airway * upper respiratory tract infection within 2 weeks * history of allergy or long-term use of propofol and opioids * self-rating anxiety scale before operation indicates anxiety * pregnancy or lactation.