The purpose of the study is to examine the benefits and mechanism of action of computerized cognitive training (CCT) on mood, neuropsychological deficits, everyday functioning, and brain activity among young adults with a range of depressive symptoms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
28
Participants will complete 8 weeks of computerized cognitive training through the Peak platform on mobile devices.
This group will not receive computerized cognitive training.
Queens College
New York, New York, United States
Change in Sheehan Disability Scale
Self-report questionnaire of everyday functioning. It includes three subscales: work, social life, leisure activities, and home life or family responsibilities. Each subscale is rated on a 10-point scale for a minimum total score of 0 and a maximum total summed score of 30 across the three subscales. High scores are associated with more impairment.
Time frame: Screen, Week 0, Week 4, Week 8, 3-month follow-up
Change in Hamilton Depression Rating Scale
Clinician-rated measure of depression composed of 21 questions. The first 17 items are scored: eight items have a 5-point scale, nine items have a 3-point scale. Total score range is 0-52. Higher scores indicate more severe symptoms.
Time frame: Screen, Week 0, Week 4, Week 8, 3-month follow-up
Change in DKEFS Trail Making Test - Condition 4
Measure of executive function. It is a switching task that requires the subject to connect numbers and letters in an alternating pattern (1-A-2-B, etc.) as quickly as possible.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in Emotional Go/No Go Task (fMRI)
Measure of behavioral inhibition and set shifting. Participants must press a button for pre-specified to go trials and withhold pressing the button for pre-specified no-go trials.
Time frame: Week 0, Week 4 or Week 8 (depending on randomization)
Change in Beck Depression Inventory-II
Self-report questionnaire of depression composed of 21 questions on a 4-point scale. Total score ranges from 0-63. Higher scores indicate worse symptom severity.
Time frame: Screen, weekly for weeks 0-8, 3-month follow-up
Change in WAIS-IV Coding
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Participants are required to copy symbols paired with numbers in a 120 second time limit. The score is the number correct in the allotted time.
Time frame: Weeks 0, 4, 8, 3-month follow- up
Change in Connectivity Index (resting state fMRI)
Measure of resting state fMRI. Higher scores indicate more connectivity within the network
Time frame: Week 0, Week 4 or Week 8 (depending on randomization)