Multicentric prospective and retrospective register collecting patient with CML blast crisis diagnosed in Germany and Europe
Since the advent of treatment with tyrosine kinase inhibitors (TKI), the incidence of blast crises has significantly decreased. Nevertheless, about 5% of patients diagnosed with chronic myeloid leukemia (CML) will evolve into a blast phase at some point during the course of their disease. Furthermore, despite the advances made in CML treatment, outcome of patients with blast crises are still dismal. Due to the rarity of this condition clinical trials are challenging, and collaboration between researchers both at national and international level is needed to collect a meaningful number of data.
Study Type
OBSERVATIONAL
Enrollment
250
Masaryk University Hospital Brno
Brno, Czechia
RECRUITINGUniversitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
Dresden, Germany
RECRUITINGUniversitätsklinikum Essen
Overall survival
how many patients survive after a blast crisis event
Time frame: through study completion in 2024
Rate of hematologic response to treatment
how many patients have a hematologic response to the local standard Treatment after a blast crisis event
Time frame: through study completion in 2024
Rate of molecular response to treatment
how many patients have a molecular response to the local standard Treatment after a blast crisis event
Time frame: through study completion in 2024
Rate of blast crises in Europe in the era of TKI treatment
how many patients have blast crisis events compared to all treated CML-patients in the trial centers
Time frame: through study completion in 2024
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Essen, Germany
University Hospital Jena
Jena, Germany
RECRUITINGUniversitätsklinikum Leipzig AöR
Leipzig, Germany
RECRUITINGUniversitätsmedizin Mannheim
Mannheim, Germany
RECRUITINGUniversitaetsklinikum Muenster
Münster, Germany
RECRUITINGI. P. Pavlov First St. Petersburg State Medical University
Saint Petersburg, Russia
RECRUITINGNational Research Center for Radiation Medicine
Kiev, Ukraine
RECRUITING