Age-related macular degeneration (AMD) is the leading cause of blindness among adults in North America. The current standard of care for patients with exudative ("wet") AMD is anti-vascular endothelial growth factor (anti-VEGF) therapy which must be administered by an injection into the eye every 4-8 weeks. MT-0814 is being developed for the treatment of patients with exudative AMD, and could offer an alternative, safer and less burdensome therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
13
Senju Investigational Site
Peoria, Arizona, United States
Senju Investigational Site
Phoenix, Arizona, United States
Senju Investigational Site
Pasadena, California, United States
Change in Best-corrected Visual Acuity (BCVA) : Study Eye
Change from Baseline in BCVA. BCVA was measured using an eye chart and is reported as number of letters read correctly using Early Treatment of Diabetic Retinopathy Study (ETDRS) Scale (0 to 100 letters) in study eye. Lower number of letters read correctly, worse the vision. Study eye: eye that meets inclusion criteria. If both eyes meet all inclusion and exclusion criteria, the eye with the lower BCVA at Screening will be selected as the study eye. If both eyes meet all inclusion criteria and have identical BCVA at Screening, selection of the study eye will be at the investigator's discretion.
Time frame: Baseline and Week 12
Change in Central Subfield Thickness (CSFT) : Study Eye
Change from Baseline in CSFT, measured by Optical Coherence Tomography (OCT). Study eye: eye that meets inclusion criteria. If both eyes meet all inclusion and exclusion criteria, the eye with the lower BCVA at Screening will be selected as the study eye. If both eyes meet all inclusion criteria and have identical BCVA at Screening, selection of the study eye will be at the investigator's discretion.
Time frame: Baseline and Week 12
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Senju Investigational Site
Redlands, California, United States
Senju Investigational Site
Altamonte Springs, Florida, United States
Senju Investigational Site
Clearwater, Florida, United States
Senju Investigational Site
Melbourne, Florida, United States
Senju Investigational Site
Tallahassee, Florida, United States
Senju Investigational Site
Arlington, Texas, United States
Senju Investigational Site
Houston, Texas, United States
...and 3 more locations