Prediction of Outcome in Severe Preeclampsia

Cairo University100 enrolled

Overview

this summary studied the predictive values of factor V Leiden mutation , doppler indices , placental pathology to unfavorable fetal and maternal outcomes

leiden mutation is activated protein C resistance with hypercoagulable states and increased thrombotic risk. 99 % are heterozygous and 1 % is homozygous , very rare cases are psoudohomozygous with factor V deficiency. relation to this mutation was studied in severe preeclamptic patients. doppler indices of uterine arteries , increased pulsetility index or unilateral or bilateral uterine artery notch and placental pathology were studied.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Leiden Factor V Deficiency,Preeclampsia Doppler Examination Palental Pathology

Interventions

blood sample , doppler of uterine vessel and placentaDIAGNOSTIC_TEST

blood sample for factor V and doppler examination of uterine arteries , placenta pathology post partum

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: severe preeclampsia in 3rd trimester - Exclusion Criteria:Twin pregnancy. Fetal congenital anomalies. Diabetic patient, impaired renal function. Any medical disorders even that HTN. Any placental pathology,Autoimmune diseases. Women with uterine activity or clinical emergencies with maternal hemodynamic instability or an indication for immediate termination of pregnancy. \-

Outcomes

Primary Outcomes

percentage of patients develop abruption placenta, intrauterine growth retardation or delivered premature

placental abruption, prematurity, IUGR

Time frame: within 12 wks from diagnosis of severe preeclampsia

percentage of fetuses and neonates complicated with intrauterine fetal death or need admission to incubator

IUFD, admission to neonatal IUC

Time frame: from diagnosis of severe preeclampsia till one week after delivery

Data from ClinicalTrials.gov

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