The purpose of this study is to evaluate the safety of SHR-1702 monotherapy or in combination with Camrelizumab among advanced solid tumor subjects.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
8
Administered IV
Administered IV
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Number of Participants with DLTs
Time frame: Approximately 28 Days
ORR: Percentage of Participants With a CR or PR
Time frame: Approximately 2 years
Safety and tolerability of SHR -1702 using Common Terminology Criteria for Adverse Events.
Time frame: Dose Escalation Part -- Approximately 2 years
Immunogenicity as assessed by the presence of anti-drug antibodies
Time frame: Approximately 2 years
Pharmacodynamic profile as assessed by receptor occupancy
Time frame: Approximately 2 years
PK Parameter: Maximum Concentration (Cmax)
Time frame: Approximately 2 years
PK Parameter: AUC, 0 to infinity
Time frame: Approximately 2 years
PK Parameter: Clearance (CL)
Time frame: Approximately 2 years
PK Parameter: Cmin at steady state (Cmin,ss)
Time frame: Approximately 2 years
PK Parameter: Cmax at steady state (Cmax, ss)
Time frame: Approximately 2 years
PK Parameter: terminal half-life (t1/2)
Time frame: Approximately 2 years
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