In the presented study, autonomic function as well as risk for atrial fibrillation will be assessed to characterize the relation between risk of atrial fibrillation and autonomic function.
Atrial fibrillation (AF) has been suggested as relevant comorbidity in patients with chronic obstructive pulmonary disease (COPD). The evaluation of the total atrial conduction time via tissue Doppler imaging (PA-TDI interval) can be used to identify patients with increased risk of new onset AF. Autonomic function can be assessed by different non invasive clinical investigations. The investigators hypothesise that PA-TDI interval is increased in acutely exacerbated COPD (AECOPD) compared within stable COPD and that increased PA-TDI is related to impairment of autonomic function. For this purpose, 25 patients with AECOPD and 25 patients with stable COPD were characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and autonomic function.
Study Type
OBSERVATIONAL
Enrollment
50
Measurement of lung function, electrocardiography, echocardiography and autonomic function
University Hospital Düsseldorf, Division of Cardiology, Pulmonary Disease and Vascular Medicine
Düsseldorf, Germany
total atrial conduction time
total atrial conduction time via tissue Doppler imaging (PA-TDI interval)
Time frame: Baseline
Heart rate variability
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Time frame: Baseline
Baroreflex sensitivity
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Time frame: Baseline
Chemoreflex sensitivity
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Time frame: Baseline
Deep breathing test
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Time frame: Baseline
Ewing test
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Time frame: Baseline
Cold pressure test
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
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Time frame: Baseline
Cold face test
For the assessment of autonomic function different test that characterize sympathetic or parasympathic function are performed. All tests for autonomic function are non invasive.
Time frame: Baseline