Fish collagen hydrolysates or peptides orally administered have been investigated in recent clinical trials in human health. These peptides have been evaluated in various biological and medical fields including skin aging, osteoarticular apparatus, muscle and more recently in energy metabolism in both animals and humans. However, very few studies investigated the effect of fish collagen peptides on weight, body composition or glycemic response. Recently, it has been shown that the consumption of fish collagen peptides (Naticol®) limits weight gain and increase in fat mass in a mouse model made obese by a hyperlipidic diet. Since these results have never been observed in humans, this pilot study proposes to answer this question.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
Consumption of a non active food complement during 3 months. Tests performed : * 2 blood tests : * 2 body composition analysis via Dual-energy X-ray absorptiometry (DXA) * 2 stool collections The first one of these analysis was performed at the beginning, second at the end of the study.
Consumption of the active food complement during 3 months containing Naticol. Tests performed : * 2 blood tests : * 2 body composition analysis via Dual-energy X-ray absorptiometry (DXA) * 2 stool collections The first one of these analysis was performed at the beginning, second at the end of the study.
NutrInvest - Institut Pasteur de Lille
Lille, Nord, France
Weight of participants
Weight is expressed in kilograms
Time frame: 0 and 3 months
Body composition par DXA analysis
Fat mass is expressed in kg and percent, muscle mass in kg and percent.
Time frame: 0 and 3 months
Waist circumference
Data are expressed in centimeters
Time frame: 0 and 3 months
Lipid profile in plasma
Total cholesterol, HDL cholesterol, LDL cholesterol, and Triglycerides. Data are expressed in g/L and in mmol/L
Time frame: 0 and 3 months
Glycemia level in plasma
Data are expressed in g/L and mmo/L
Time frame: 0 and 3 months
Insulin level in plasma
Data are expressed in μU/ml
Time frame: 0 and 3 months
HOMA index
This index indicates the insulin resistance and was calculated as follow : HOMA \[(glycémie mmol/l X insulinémie μU/ml) à jeun / 22,5\]
Time frame: 0 and 3 months
Physical activity intensity
Score obtained via Ricci and Gagnon questionnaire. The questionnaire contains 9 questions ; score could be between 9 and 45 points. * under 18 points : inactive behavior * between 19 and 35 points : active behavior * over 35 points : very active behavior
Time frame: 0 and 3 months
Pro-inflammatory cytokines concentration
Assay for TNFalpha, IL-1beta and IL-6 in plasma
Time frame: 0 and 3 months
Microbiota analysis
Rate comparison of different bacteria families
Time frame: 0 and 3 months
Height
centimeters
Time frame: 0
Body mass index
kg/m²
Time frame: 0 and 3 months
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