Parathyroid Hormone Kinetics During CRRT

Uniwersytecki Szpital Kliniczny w Opolu30 enrolled

Overview

The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation continuous renal replacement therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critical Illness Multi Organ Failure Renal Failure Circulatory Failure Respiratory Failure

Interventions

parathyroid hormoneDIAGNOSTIC_TEST

10-20ml blood samples taken from the arterial catheter every 12 hours to obtain parathyroid hormone serum concentration. 6-8 samples per patient

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute respiratory failure * Acute circulatory failure * acute kidney injury treated with regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (CVVHDF * continuous renal replacement therapy started no later than 48 hours after admission * SOFA score 5 or more Exclusion Criteria: * age less than 18 years * acute liver failure * hypercalcemia at admission (total calcium plasma level \> 10.6 mg/dL; total ionized calcium plasma level \> 1.35 mmol/L * parathyroid glands disease * end stage renal disease * therapeutic plasma exchange * extracorporeal membrane oxygenation * unfavorable outcome (death) predicted within 72 hours (as assessed by investigator) * lack of relatives consent

Locations (3)

Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland.

Wroclaw, Lower Silesian Voivodeship, Poland

Department of Endocrinology, Szpital Wojewodzki w Opolu

Opole, Silesian Voivodeship, Poland

Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu

Opole, Silesian Voivodeship, Poland

Outcomes

Primary Outcomes

The change in parathyroid hormone serum concentration during regional citrate anticoagulation continuous renal replacement therapy (CRRT) in the acute phase of critical illness.

The first parathyroid hormone serum level will be measured before the start of CRRT (the zero point) Next measurements will be performed every 12 hours. Minimal number of measurements - 6, maximal - 8 per patient.

Time frame: 96 hours

Data from ClinicalTrials.gov

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