Pipeline™ Vantage Embolization Device With Shield Technology™ for Wide-Necked Intracranial Aneurysms (ADVANCE)

Inclusion Criteria (Imaging): * Subject has a target intracranial aneurysm located in the internal carotid artery (up to the terminus). * Subject has a target intracranial aneurysm with an aneurysm neck ≥4mm or a dome-to-neck ratio of \< 2. * Subject has a target intracranial aneurysm that has a parent vessel with diameter 1.5-5.0 mm distal/proximal to the target intracranial aneurysm. Inclusion Criteria (Clinical): * Subject (or subject's legally authorized representative) has provided written informed consent using the IRB and Medtronic approved Informed Consent Form and agrees to comply with protocol requirements. HIPAA/data protection authorization has been provided and signed by the subject (or subject's legally authorized representative). * Age 22-80 years at the time of consent. * Life expectancy ≥3 years * Subject has a mRS ≤ 2 at baseline to be determined by a certified independent assessor at the site. * Subject has already been selected for endovascular treatment of the target aneurysm. * Subject's last recorded P2Y12 reaction units (PRU) value is between ≥60 and ≤200 prior to study procedure. * Subject has multiple increased risk factors for intracranial aneurysm rupture, including but not limited to, aneurysm morphology, smoking, hypertension, diabetes, age, prior and/or family history of rupture, and/or history of subarachnoid hemorrhage that may result in a benefit risk profile of endovascular treatment to outweigh the risks of intracranial aneurysm rupture during the subject's expected lifetime if left untreated. Exclusion Criteria (Imaging): * Subject has internal carotid artery bifurcation aneurysm. * Aneurysms that arise from the Posterior Communicating Artery (PComm). * The internal carotid artery aneurysms of the C7 segment will be excluded under the following conditions: 1. Observed fetal posterior communicating artery (PComm) of fetal origin (A PComm of fetal origin is defined as a small, hypoplastic, or absent P1 segment of the posterior cerebral artery (PCA) with the PComm artery supplying a majority of blood flow to the P2 and higher order segments of the PCA) 2. PComm overlapping with the aneurysm neck 3. PComm branch arising from the dome of the aneurysm * Subject has aneurysm arising from internal carotid artery but is primarily fed by posterior circulation (i.e., retrograde flow from the basilar artery) as confirmed by DSA Exclusion Criteria (Clinical): * Subject requires treatment of another aneurysm (with another treatment modality) within the affected territory of the target aneurysm during the study period. * Subject has received an intracranial implant (e.g. coils) in the area of the target intracranial aneurysm within the past 6 months prior to the study procedure. * Subject has had a SAH and/or target aneurysm rupture in the past 30 days prior to the study procedure. * Subject has undergone a surgery including endovascular procedures in the last 30 days prior to the study procedure. * Aneurysm vessel characteristics (e.g. parent vessel stenosis, irregular morphology) that would preclude the device from fully confirming to the parent vessel to reduce any risk of embolic complications, retreatment, or device movement. * Subject has active vasospasm, malignant brain tumor or vascular malformation (e.g. arteriovascular malformation). * History of major bleeding disorder (based on coagulation profile and platelet count) and/or subject presents with signs of active bleeding. * Subject requires adjunctive device use (e.g. coils) during the index procedure. * Subject has extradural target aneurysm \<12mm which is not symptomatic or not exhibiting aneurysm growth (exception: unless it is a fusiform aneurysm \<12 mm i.e., asymptomatic extradural fusiform aneurysms \<12 mm can be included). * Any known contraindication to treatment with the Pipeline™ Vantage Embolization Device with Shield Technology™, or use of antiplatelet therapy including: 1. Active bacterial infection 2. Contraindication to DAPT agents * Pre-existing stent is in place in the parent artery at the target intracranial aneurysm location * Platelet count \< 100 x 10\^3 cells/mm\^3 or known platelet dysfunction. * The Investigator determines that the health of the subject or the validity of the study outcomes (e.g., high risk of neurologic events, conditions that may increase the chance of stroke) may be compromised by the subject's enrollment. * Subject is pregnant or wishes to become pregnant during the first year of study participation. * Subject is participating in another clinical trial at any time during the duration of the study that could confound the treatment or outcomes of this investigation. * Subject with known allergy to platinum or cobalt chromium alloy (including the major elements platinum, cobalt, chromium, nickel or molybdenum). * History of previous acute ischemic stroke * Subject is unable to undergo DSA or CTA imaging at follow-up