Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor

Mayo Clinic9 enrolled

Overview

Researchers are investigating improved methods of targeting deep brain stimulators for treatment of essential tremor relying on brain connectivity measures derived from MRI.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Essential Tremor

Interventions

Functional MRIDIAGNOSTIC_TEST

A special type of MRI measuring the metabolic changes that occur within the brain. It may be used to examine the brain's anatomy and determine which parts of the brain are handling critical functions. It helps identify important language and movement control areas in the brain.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of refractory essential tremor scheduled for unilateral thalamic deep brain stimulator placement * Age ≥ 18 years Exclusion Criteria: * Prior deep brain stimulator, stereotactic radiosurgery, or focused ultrasound procedure for treatment of tremor * Presence of concomitant movement disorder (e.g. Parkinson's disease, dystonia, etc.) * Known pre-existing structural brain abnormality (e.g, infarction, tumor, prior brain surgery, etc.) * Contraindication to 3 Tesla brain MRI (e.g. incompatible implanted device) * Pregnant

Locations (1)

Mayo Clinic in Florida

Jacksonville, Florida, United States

Outcomes

Primary Outcomes

Change in tremor rating score

Fahn, Tolosa, Marin Tremor Rating Scale 1-9 Tremor (rate tremor) 0 = None 1. = Slight. 2. = Moderate amplitude. 3. = Marked amplitude 4. = Severe amplitude 0 = Normal 1. = Mildly abnormal. 2. = Moderately abnormal. 3. = Marked abnormal. 4. = Severely abnormal.

Time frame: One year

Data from ClinicalTrials.gov

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