Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose the use of probiotics to improve the clinical evolution of septic acute kidney injury patients.
Acute kidney injury is most commonly caused by sepsis, where endotoxemia and an expanding inflammatory reaction play a key role in its pathogenesis, when this condition is present it is highly related to poor clinical outcomes and higher mortality rates. There is no current specific treatment, and the therapeutic approach is more orientated to complication management. In this study, the investigators propose the use of probiotics to improve the clinical evolution of septic acute kidney injury patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
90
Administration of oral probiotics with 2 doses a day
Administration of oral placebo with 2 doses a day
HCG
Guadalajara, Jalisco, Mexico
RECRUITINGSerum creatinine
Number of participants with significative reduction of serum creatinine concentration from beginning of the intervention
Time frame: 7 days
Death
Number of defunctions among the subjects
Time frame: 7 days
Renal replacement therapy
Number of participants that initiate renal replacement therapy
Time frame: 7 days
Final creatinine
Last recorded serum creatinine concentration
Time frame: 7 days
Urinary output (final)
Quantification of urinary output in ml/Kg/hour
Time frame: 7 days
Shock days
Use of vasopressor therapy during hospitalization
Time frame: 7 days
Recuperation of basal creatinine
Serum creatinine reduction to 25% from basal creatinine
Time frame: 7 days
Length of hospitalization
Days of hospitalization
Time frame: 7 days
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