Mesenchymal Stem Cells (MSCs) - Like Cell Transplantation in Women With Primary Ovarian Insufficiency

Inclusion Criteria: 1. Under 40 years of age; 2. Have established regular menstrual cycle, oligomenorrhea / amenorrhea ≥ 4 months; 3. FSH (Follicle-Stimulating Hormone) \> 25 IU/mL; 4. Bilateral ovaries are visible by ultrasound; 5. Have fertility requirement, husband has sperms; 6. Willing to sign the Informed Consent Form. Exclusion Criteria: 1. Primary amenorrhea; 2. History of serious drug allergy or allergic constitution; 3. Thrombophlebitis and thromboembolia, past and present; 4. Acute or chronic infection, hematologic disease, angiocardiopathy, pulmonary disease, liver disease, nephropathy, pancreas disease 5. Autoimmune disease, history of severe familial genetic disease, etc. 6. Anatomical abnormality of reproductive system; 7. Contraindications for pregnancy; 8. Spouse azoospermia; 9. HIV+, hepatitis B, C; 10. Thyroid dysfunction; 11. History of previous malignant or ovarian tumors, history of ovarian therapy; 12. Abnormal karyotyping (e.g. turner syndrome, fragile X syndrome); 13. During pregnancy or lactation; 14. Alcohol or other substance abuse; 15. Mental disease, communicate obstruction; 16. Unwilling to comply with follow-up schedule or want to take other treatment during the follow-up period; 17. Attending doctor consider inappropriate to take part in.