Monitoring of inflammatory substances (such as interleukins, CRP, albumine), and markers of organ dysfunction (such as creatinine, proenkephaline, amylase, troponine, IFABP and lactate) during elective liver resection. The study also includes monitoring of hemodynamic parameters, blood loss and postoperative complications. Results are to be used för power calculation for future trials.
During hepatic surgery, blood and urine samples will be obtained at 3 times during surgery, at 3 h after resection of liver, at 24 h after resection of liver and at post operative day 2, and subsequntly analyzed for the above mentioned substances. Routine labs will be monitored until patient is discharged from hospital. During surgery, hemodynamic parameters will be monitored by Picco calculations. Urine output and blood loss will be registred.
Study Type
OBSERVATIONAL
Enrollment
18
none, descriptive study
SahlgrenskaUH
Gothenburg, Västra Götaland County, Sweden
Ischemic Intestinal Damage
rise in IFABP in nanograms/ml,
Time frame: from day of surgery until 24-48 hours postoperatively
Kidney injury
as described by KDIGO (Kidney Disease Improving Global Outcomes) criteria
Time frame: from day of surgery and approximately 1 week onwards
Intestinal Bacterial Transloction
Rise in D-lactate in micromol/ml
Time frame: from day of surgery until 24-48 hours postoperatively
Kidney injury
proenkephaline increase in pico mol/l
Time frame: from day of surgery until 24-48 hours postoperatively
Kidney injury
NAG units/g increase in urine.
Time frame: from day of surgery until 24-48 hours postoperatively
Description of Inflammatory Response
Changes in MCP-1, SDF-1, IL-1beta, TNF-alfa, IL-6, IL-8, IL-10 and HMBG-1, in blood samples obtained during and after heptaic surgery
Time frame: from day of surgery and approximately 1 week onwards
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.