4-methylpyrazole and Acetaminophen Metabolism

Early Phase 1CompletedNCT03878693

University of Arizona6 enrolled

Overview

Oxidative metabolism of APAP will be studied with and without 4-MP.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Healthy Adult Volunteers

Interventions

FomepizoleDRUG

IV 4-MP.

APAPDRUG

Oral APAP

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * No APAP use in previous 2 weeks * No ingestion of alcohol or drugs that affect CYP 2E1 over previous 5 days * No allergy to APAP or fomepizole * BMI \< 29 Exclusion Criteria: * Pregnant or lactating * History of alcohol abuse * Allergy to APAP or fomepizole * Screening LFTs above normal range

Locations (1)

BUMCP - Department of Medical Toxicology

Phoenix, Arizona, United States

Outcomes

Primary Outcomes

Oxidative metabolism of APAP

Measurement of oxidized metabolites of APAP

Time frame: 24 hours

Data from ClinicalTrials.gov

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