This study aims to validate a non-invasive method of chromosomal screening (NICS), based on the Multiple Annealing and Looping Based Amplification Cycles- Next-generation Sequencing (MALBAC-NGS) technology, in order to determine the chromosomal endowment of a blastocyst from the DNA of the embryonic culture medium. The chromosomal status of the embryo from an embryo biopsy of trophoectoderm will be established (usual clinical practice), the chromosomal endowment from the DNA of the embryonic culture medium will be determined, and the results using the NICS and the conventional invasive method (Preimplantation Genetic Testing for Aneuploidy \[PGT-A\]) will be compared.
Study Type
OBSERVATIONAL
Enrollment
50
Screening based on MALBAC-NGS technology
Instituto Bernabeu
Alicante, Spain
Presence of Mosaicism
Presence of mosaicism
Time frame: At Day 5-6 after FIV
Quality value of NICS DLRS
Quality value of noninvasive chromosome screening (NICS) derivative Log Ratio Spread (DLRS)
Time frame: At Day 5-6 after FIV
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