Resistance Training in People Living With HIV/AIDS

State University of Maringá49 enrolled

Overview

The aim of this study will be to verify effects of resistance training in people living with HIV/AIDS.

The aim of this study was verify effects of resistance training in cognitive function, body composition and biochemical parameters of inflammation and oxidative stress in people living with HIV/AIDS. The sample was composed by patients with HIV/AIDS of both sexes. The patients were randomized in two groups, a exercise group (EG), which was receive intervention with eight weeks of resistance training, and a control group (CG), that was not to do exercise. The cognitive function was analyzed with Stroop Test and Trail Test; body composition was evaluated by bioimpedance; blood tests was use to analyze biochemical parameters of inflammation and oxidative stress. For statistical analysis was used ANOVA of two factors for repeated measurements, having the (EG and PG) group and the time (pre and post exercise). Level of significance adopted was P \< 0,05.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

HIV/AIDS

Interventions

Exercise groupOTHER

Resistance training 3 times per week (45-60 minutes of resistance training)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnostic for HIV/AIDS. * Clinical condition and viral count stabilized. * Have been using (HAART) for 6 months or more. * Not have participated in physical exercise programs in six months before beginning of study. * Not have muscle or joint injuries that make it impossible to practice physical activity. * Not be pregnant. Exclusion Criteria: * Not attending more than 15% of the intervention sessions or visits to the laboratory. * Aggravation of the disease. * Stick to a physical activity program in addition to that offered by the study.

Locations (1)

State University of Maringá

Maringá, Paraná, Brazil

Outcomes

Primary Outcomes

Change in Cognitive Function

Victoria Stroop, Castro Cunha \& Martins Stroop and Trail Test were performed at baseline and after eight weeks of intervention in both groups (EG and CG). Blood will be collected and brain-derived neurotrophic factor (BDNF) will be measured by Enzyme-Linked Immunosorbent Assay Method (Human - ELISA Kit) at baseline and after eight weeks of intervention in both groups (EG and CG).

Time frame: Baseline and eight weeks

Secondary Outcomes

CD4 / CD8

Blood was collected and cluster of differentiation 4 (T CD4+) and cluster of differentiation 8 (T CD8+) cells was measured by flow cytometry (BD TrucountTM Tubes) with FACSCalibur (Dickinson, New Jersey, USA) at baseline and after eight weeks of intervention in both groups (EG and CG).

Time frame: Baseline and eight weeks

Concentration of Inflammatory markers

Blood was collected and interferon (INF-y), interleukin 4 (IL-4), interleukin 6 (IL-6) and interleukin 10 (IL-10) was be measured by Enzyme-Linked Immunosorbent Assay Method (Human - ELISA Kit) at baseline and after eight weeks of intervention in both groups (EG and CG).

Time frame: Baseline and eight weeks

Health cellular

Cellular health was evaluated through phase angle value using the bio-electrical bioimpedance method (Biodynamics 450 analyzer, Biodynamics Corporation, Seattle, USA) at baseline and after eight weeks of intervention in both groups (EG and CG).

Time frame: Baseline and eight weeks

Data from ClinicalTrials.gov

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