PACAP38 Induced Headache, Migraine and Flushing in Patients With Migraine

Inclusion Criteria: * diagnosis of migraine, according to IHS criteria * weight between 50 - 100 kilograms * women in fertile age must not be pregnant and must use adequate contraception Exclusion Criteria: * migraine more than 5 days per month in average over the past year * any primary headache other than migraine, apart from tension-type headache which must be less than 5 days per month * headache \< 48 hours before experimental day * migraine \< 72 hours before each experimental day * daily / frequent use of any medication apart from contraceptive medication * use of any drug less than 5 times the half-life of the drug at the time of the experiment * women who are pregnant or breast-feeding at the time of the experiment * anamnestic or clinical signs of hypertension (systolic blood pressure \> 150 mmHg and/or * diastolic blood pressure \> 100 mmHg) or hypotension (systolic blood pressure \< 90 mmHg and/or diastolic blood pressure \< 50 mmHg) * anamnestic or clinical signs of mental illness, or abuse of alcohol / drugs * patients with glaucoma or prostate hyperplasia * anamnestic or clinical symptoms of any sort that the investigating doctor deemed unfit for participating in the study