To compare 25(OH)D level in patients with pre-eclampsia, eclampsia and normotensive pregnant women as well as to study the prevalence of Vitamin D deficiency among the 3 groups.
200 patients with pre-eclampsia, 100 with eclampsia and 200 normotensive pregnant controls attending Delivery/emergency department in Kasr Al Ainy hospital will be included in the study (from March 2019 till September 2019). 25(OH) D level will be measured for the three groups. * Preeclampsia is defined as systolic BP \>140 and/or diastolic BP\>90 on two occasions, 4 hours apart in pregnant females\>20 weeks, plus proteinuria \>/= 1+ urine dipstick protein. * Eclampsia defined as tonic-clonic seizures in women with pre-eclampsia. * Controls are normotensive pregnant females with no proteinuria and no other medical disorders. * The determination of 25(OH) D is based on a competitive enzyme-linked immunosorbant assay (ELISA) using the 25(OH)D3/D2 ELISA system (ORGENTIC DIAGNOSTIKA GmbH, Germany) Inclusion criteria: Age 20-35 years Gestational age 30-40 weeks Exclsion criteria: Twin pregnancy Other medical conditions during prrgnancy Drugs that influence Vit D levels eg.antiepileptics and antituberculous treatment.
Study Type
OBSERVATIONAL
Enrollment
500
Blood samples
Cairo University
Cairo, Egypt
RECRUITINGTo compare vitamin D levels in the three groups
Time frame: 6 months
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