Food-effect on PK and PD of Single Oral Dose of HIP1601 in Healthy Male Subjects

Inclusion Criteria: * Male/Female healthy volunteers in the age between 19 and 50 years old. * Body mass index (BMI) in the range of 19 to 28 kg/m2 and weight 55.0kg to 90.0kg. * Helicobacter pylori (H. Pylori) negative. * After fully hearing and understanding the details of this clinical trial, Subjects who have willingness to sign of informed consent before the screening. * Subject who are eligible from physical examination, clinical laboratory test by investigators judgment. Exclusion Criteria: * Gastrointestinal disorders (gastrointestinal ulcers, gastritis, stomach cramps, gastro-esophageal reflux disease, Crohn's disease or chronic pancreatitis) or gastrointestinal surgery (except for simple cecal or hernia surgery) which may affect the safety and pharmacokinetic evaluation of test drug. * Subjects who have a history of hypersensitivity or clinically significant hypersensitivity to esomeprazole or the same component or other drugs (aspirin, antibiotics, etc.). * Blood serum aspartate aminotransferase and alanine aminotransferase exceed 1.5 times the upper limit of normal range from screening laboratory results before randomization. * Subject who continues to drink (21 units / week, 1 unit = 10 g of pure alcohol) within a month before the screening visit or who cannot abstain during the hospital stay. * Heavy smoker (\>10 cigarettes/day).