The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with Type 2 diabetes. Subjects will be randomized to one of the three groups: exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 16 weeks of intervention.
Our hypothesis is that sustained activation of the GLP-1 receptor with Liraglutide or exercise training will enhance microvascular perfusion, promote angiogenesis, and improve microvascular response to insulin in muscle, leading to increased muscle delivery of oxygen and nutrients and increased exercise tolerance in subjects with type 2 diabetes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
16 weeks of treatment
16 weeks of Liraglutide
University of Virginia
Charlottesville, Virginia, United States
RECRUITINGMicrovascular Blood Volume - change from baseline
measured at baseline and 16 weeks
Time frame: 16 weeks
Augmentation Index - change from baseline
measured at baseline and 16 weeks
Time frame: 16 weeks
Flow Mediated Dilation - change from baseline
measured at baseline and 16 weeks
Time frame: 16 weeks
Pulse Wave Velocity - change from baseline
measured at baseline and 16 weeks
Time frame: 16 weeks
Post Ischemic Flow Velocity-Change from baseline
measured at baseline and 16 weeks
Time frame: 16 weeks
Insulin Sensitivity-Change from baseline
measured at baseline and 16 weeks
Time frame: 16 weeks
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