The main interest of this study is to investigate the influence of moderate alcohol consumption (beer) on salt-water homeostasis. Therefore, 10 healthy volunteers will participate in 4 Intervention: * Beer alone * Beer and water * Beer and salt (stock/bouillon) * Water alone During the study day, copeptin, sodium, osmolality and urinary sodium/osmolality will be measured at 6 timepoints.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
10
Weight adjusted beer to reach 0.8 blood alcohol content will be given over the time course of 1 hour to the participants
Weight adjusted beer to reach 0.8 blood alcohol content and water will be given over the time course of 1 hour to the participants
Weight adjusted beer to reach 0.8 blood alcohol content and stock will be given over the time course of 1 hour to the participants
University Hospital Basel
Basel, Switzerland
Difference in copeptin levels between the interventions
Difference in copeptin levels (pmol/l) between moderate beer consumption and moderate beer consumption with additional water and sodium (stock/bouillon) intake at timepoint 1.5 hours.
Time frame: 30 minutes after intervention
Change in copeptin levels between the interventions throughout the observation period of 12 hours
Change in copeptin Levels (pmol/l) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the Intervention, comparing the interventions
Time frame: Observation period of 12 hours
Change in plasma sodium levels between the interventions throughout the observation period of 12 hours
Change in plasma sodium (mmol/l) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Change in urinary sodium levels between the interventions throughout the observation period of 12 hours
Change in urinary sodium (mmol/kg) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Change in plasma osmolality levels between the interventions throughout the observation period of 12 hours
Change in plasma osmolality (mmol/kg) levels from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Change in urinary osmolality levels between the interventions throughout the observation period of 12 hours
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Water equivalent to the calculated volume of beer will be given over the time course of 1 hour to the participants
Change in urinary osmolality (mmol/kg) levels from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Change in plasma Glucose levels between the interventions throughout the observation period of 12 hours
Change in plasma glucose (mmol/l) levels from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Change in biomarkers involved in the sodium-water homeostasis between the interventions throughout the observation period of 12 hours
Change in different biomarkers (e.g., Fibroblast growth factor 21, aldosterone, renin, Interleukin 6, Interleukin 8) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours, 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Difference in urinary excretion between the interventions throughout the observation period of 12 hours
Amount of total urinary excretion (ml) at time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours and 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Change in blood alcohol content between the interventions throughout the observation period of 12 hours
Change in blood alcohol content (°/oo) from baseline to time-point 1 hour, 1.5 hours, 2.5 hours, 4 hours and 12 hours after start of the intervention, comparing the interventions
Time frame: Observation period of 12 hours
Difference in Response to lottery Experiment before and after the intervention
Change in decision making before and after the intervention, comparing the interventions
Time frame: Directly before and 30 minutes after intervention