Foxy-5 as Neo-Adjuvant Therapy in Subjects With Wnt-5a Low Colon Cancer

Inclusion Criteria: 1. Ability to understand and willingness to provide written informed consent before any trial-related activities. 2. 18 years of age or older. 3. Male or female subjects with adenocarcinoma of the colon, judged by CT or MRI as either one of the following stages per TNM classification of colon cancer (8th edition, 2017): T1-4, N1-2, M0 or T4, N0, M0 and who are considered to fulfil the local criteria for adjuvant post- operative chemotherapy after scheduled surgery. 4. Scheduling of surgery according to local practice allows at least 9 pre- surgery administrations of Foxy-5 for the subject. (Please note: surgery should not be postponed for trial purposes.) 5. Sexually active women of childbearing potential (WOCBP) and males with WOCBP partners who are randomized to the Foxy-5 Arm must use a highly effective method of contraception for the treatment duration and for 28 days after last Foxy-5. 6. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. 7. Clinical laboratory values at screening: 1. Absolute neutrophil count ≥1.5 x 109/L 2. Haemoglobin ≥ 9 g/dL 3. Platelets ≥ 100 x 109/L 4. Aspartate Transaminase (AST) and Alanine Transaminase (ALT) ≤1.5x Upper Limit of Normal (ULN) 5. Serum bilirubin ≤1.5 x the ULN 6. Creatinine clearance \>60 mL/min (determined by Cockcroft-Gault Equation). Exclusion Criteria: 1. Assessed as not suitable or unable to tolerate adjuvant chemotherapy. 2. Evidence of distant metastatic (M1) disease at Screening (N1-2 is allowed). 3. Any surgery (except tumour biopsy) or therapy with immune suppressive agents or bone marrow stimulating factors within the last two weeks prior to randomization. 4. Any active infection requiring IV antibiotic treatment at the time of screening. 5. History of hematologic or primary solid tumour malignancy. 6. Pregnant or breastfeeding women. 7. Currently participating in another trial and receiving trial therapy or received investigational therapy within 4 weeks of the first dose of Foxy-5. 8. Any other condition or treatment that, in the opinion of the Investigator, might interfere with the trial or current drug or substance abuse. 9. Inability to understand the protocol requirements, instructions and trial-related restrictions, the nature, scope, and possible consequences of the trial. 10. Unlikely to comply with the protocol requirements, instructions and trial-related restrictions; e.g., uncooperative attitude, inability to return for follow-up visits, and improbability of completing the trial. 11. Legal incapacity or limited legal capacity. 12. Any condition, which results in an undue risk for the subject during the trial participation according to the Investigator.