Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.
After clinical identification of patients with MVP, doctors organize 1st degree relative familial screening. A comprehensive echocardiography was carried out along with clinical examination. All echo data were stored for off-line analysis by a sonographer in our Core-lab. Blood was sample at the time of echocardiography in adult patients for DNA analyses. Follow-up for mitral valve changes will be performed after 5 years.
Study Type
OBSERVATIONAL
Enrollment
1,000
Brest University Hospital
Brest, France
NOT_YET_RECRUITINGNantes University Hospital
Nantes, France
RECRUITINGRennes University Hospital
Rennes, France
RECRUITINGMVP defined by a superior displacement of at least 2 mm
MVP defined by a superior displacement of at least 2 mm
Time frame: At Day 0
Comprehensive mitral valve apparatus characterization per size of items (leaflets, chordae, annulus)
Leaflets length ; Chordae length ; Annulus diameter
Time frame: At Day 0
Comprehensive mitral valve apparatus characterization per other items (papillary muscle, ventricles)
Papillary muscles aspect ; Right Ventricle function ; Left Ventricle Ejection Fraction
Time frame: At Day 0
Comprehensive mitral valve apparatus characterization per size of items (ventricle and atrium sizes)
Left ventricle and atrium sizes ; right ventricle size ; right Atrium size
Time frame: At Day 0
Comprehensive mitral valve apparatus characterization per size of items
Leaflets thickness
Time frame: At Day 0
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