Safety and Efficacy of the ANTHEM™ CR Total Knee System

Inclusion Criteria: 1. Subject is a candidate for primary total knee arthroplasty due to degenerative joint disease. 2. Subject is willing to sign and date an EC-approved consent form. 3. Subject has posterior cruciate ligament and all collateral ligaments intact in the index joint. 4. Subject is 18 to 75 years old at time of inclusion. 5. Subject plans to be available through ten (10) years postoperative follow-up. 6. Subject agrees to follow the study protocol. 7. Subject has achieved skeletal maturity as deemed by enrolling investigator. Exclusion Criteria: 1. Subject would receive the ANTHEM™ CR Total Knee System on the affected knee as a revision for a previously failed (TKA) or unicondylar knee arthroplasty (UKA). 2. Subject received TKA on the contralateral knee as a revision for a previously failed TKA or UKA. 3. Subject has a history of patellar fracture, patellectomy, or patello-femoral Instability. 4. Subject has inflammatory arthritis. 5. Subject possesses a contralateral or ipsilateral revision hip arthroplasty. 6. Subject has ipsilateral hip arthritis resulting in flexion contracture. 7. Subject has one or more of the following arthroplasties that are not fully healed and well-functioning, as determined by the Investigator: * Ipsilateral or contralateral primary total hip arthroplasty or hip resurfacing arthroplasty. * Contralateral primary TKA or UKA. 8. Inadequate bone stock which would make the procedure unjustifiable including but not limited to: severe osteopenia/osteoporosis or family history of severe osteoporosis/osteopenia as deemed by the enrolling investigator. 9. Subject has collateral ligament insufficiency. 10. Subject has an active infection or sepsis (treated or untreated) or previous intra-articular infections. 11. Subject has presence of malignant tumor, either primary or metastatic, or benign tumor on leg with the knee to be treated. 12. Subject has conditions that may interfere with the TKA survival or outcome (e.g. Paget's or Charcot's disease, vascular insufficiency, muscular atrophy, uncontrolled diabetes mellitus \[i.e. not under treatment with oral/injectable medications to control blood glucose levels\], fibromyalgia, moderate to severe renal insufficiency or neuromuscular disease). 13. Subject has contralateral lower extremity condition causing abnormal ambulation (e.g. ankle fusion, ankle arthroplasty, previous hip fracture). 14. Women who are pregnant, nursing, or of child-bearing potential who are not utilizing highly effective birth control measures. 15. Subject has an emotional or neurological condition that would pre-empt their ability or willingness to participate in the study, including mental illness, mental retardation, drug or alcohol abuse. 16. Participation in the treatment period of another clinical trial within thirty (30) days of Visit 1. 17. Any subject that meets the definition of a Vulnerable Subject per ISO14155:2011: individual whose willingness to volunteer in a clinical investigation could be unduly influenced by the expectation, whether justified or not, of benefits associated with participation or of retaliatory response from senior members of a hierarchy in case of refusal to participate.