Source Monitoring Déficit in Neuropsychiatric Population

Hôpital le Vinatier300 enrolled

Overview

the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.

Source-monitoring abilities will be measured thanks to reality-monitoring testing (i.e. the ability to distinguish internal-generated events from external ones) and internal-monitoring testing (i.e. the ability to distinguish an imagined source from a performed one). A source-monitoring deficit have been demonstrated in patients with psychiatric conditions such as schizophrenia and seems linked to frontotemporal abnormalities (frontotemporal dysconnectivity and temporal hypoactivity). With a total of 150 patients, the investigators will include 30 patients per group: patients with pre-dementia stage Alzheimer, Alzheimer, Fronto-Temporal dementia, Lewy Body dementia or Parkinson and Bipolar Disorder, with the hypothesis that Bipolar Disorder patients will present less marked deficit. The investigators will recruit 150 healthy controls.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

300

Conditions

Psychiatric Disorder

Interventions

Monitoring source testOTHER

Internal- and external-monitoring correct responses and inversions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects who gave their free and informed consent; * Men and women; * Aged 18 to 80; * Having normal or corrected vision; * Mastering the French language (read and spoken); * All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of \<MMSE \<26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013). Exclusion Criteria: * Inadmissibility of the consent or refusal of the subject. * Patients under guardianship

Locations (1)

Centre Hospitalier Le Vinatier

Bron, Auvergne-Rhône-Alpes, France

RECRUITING

Outcomes

Primary Outcomes

measure source memory performance

in patients with neuropsychiatric disorders with or without temporal involvement (pre-dementia Alzheimer's disease, Alzheimer's disease - AD, fronto-temporal dementia - DFT, Lewy body dementia - DCL and bipolar disorder - TBP) and healthy volunteers matched in age, gender, and level of education.

Time frame: one year

Secondary Outcomes

measure the recognition of distractors

words not presented during the source monitoring test phase but presented during the recall phase. This measure will allow us to avoid that a disturbance invading the working memory or attentional capacities does not compromise the good realization of the task.

Time frame: one year

Central Contacts

JEROME BRUNELIN, PHD

CONTACT

00334 37 91 55 65 jerome.brunelin@ch-le-vinatier.fr

Jean-Michel DOREY, PHD

CONTACT

00334 37 91 52 49 jean-michel.dorey@ch-le-vinatier.fr

Data from ClinicalTrials.gov

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