HEC53856 Phase 1 Study - Single and Multiple Oral Dosing in Healthy Volunteers

Inclusion Criteria: * healthy volunteers * age: 18-45 years old(18 and 45 included). * B.W. male\> 50kg, female\> 45kg, BMI - 18-28 kg/m\^2 * females must not be pregnant and males and females must agree to use contraception during the study. * able to give informed consent and comply with protocol. * physical examination and vital signs without clinically significant abnormalities. * agree to use contraceptive methods after informed consent acquisition through 6 months after the last administration of the study drug. Exclusion Criteria: * history or presence of severe gastrointestinal or systemic disorders (e.g. respiratory, endocrine, immunological, dermatological, neurological, psychiatric, renal, hepatic disease etc.) * history or presence of significant alcoholism or drug abuse within past 5 years * smokers, who smoke more than 5 cigarettes per day within past 3 months * heavy drinker, namely alcohol consumption are 14 units per week (1 unit = 285 mL of beer, or 25 mL of strong wine, or 100 mL of grape wine); * donated blood or massive blood loss within 3 months before screening (\>450 mL） * have any disease that increases the risk of bleeding or thrombus, such as acute gastritis or stomach and duodenal ulcers; * clinically significant laboratory findings during screening * history or presence of clinically significant ECG abnormalities * participated in drug research study within past 3 months * used over-the-counter/ prescription/ herbal medications/ supplements within past 14 days. * Strenuous activity (as assessed by the investigator) is prohibited from 2 weeks prior to admission until discharge from the unit. * female in pregnancy or lactation. * viral hepatitis（including CHB and CHC）and positive test result of anti-HIV Ab or syphilis. * the investigator believes that the one should not be included