LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs

Inclusion Criteria: * Patient age \>18 years; * Lack of language barrier; * Informed consent obtained; * Presenting for primary total shoulder arthroplasty (TSA), both anatomic and reverse, by a specialty-trained surgeon; * American Society of Anesthesiology (ASA) physical status score I- III Exclusion Criteria: * Presence of a language barrier; * Inability to complete telephone and/or paper questionnaire; * Lack of consent; * Allergy to local anesthetic; * Chronic pain syndrome and/or preoperative opioid use \> 50 MME per day (including extended-release formulations and methadone); * Preoperative consultation to chronic pain service; * History of (\<3 months) or current substance abuse, including any illicit drugs or excessive alcohol consumption as defined by the Office of Disease Prevention and Health Promotion (4 or more drinks per day or 8 or more drinks per week for women and 5 or more drinks per day or 15 or more drinks per week for men); * Baseline peripheral neuropathy of the brachial plexus; * Contraindication to receiving single shot peripheral nerve blockade; including antithrombotic medications as per most recent American Society of Regional - - -Anesthesiology (ASRA) guidelines 17 , coagulopathy or coagulation disorder, or infection at injection site; * Severe chronic obstructive pulmonary disease (COPD) or other significant pulmonary disease where interscalene nerve block would be contraindicated due to concern for respiratory failure from phrenic nerve palsy; * Weight \< 45 kg, given concern for local anesthetic toxicity at dosages given for the study; ASA score IV-V; * Revision arthroplasty; * Anatomic abnormality that limits or prevents the patient from receiving an interscalene nerve block; * Pregnant, nursing, or planning to become pregnant during the study or within 1 month after the shoulder replacement surgery