Evaluate the effect of a fasting mimicking diet and a food supplement on the microvascular health and urinary heparanase levels in South Asian type 2 diabetic patients with albuminuria.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
56
5-day fasting mimicking diet
Food supplement
Placebo
Leiden Universitiy Medical Center (LUMC)
Leiden, North Holland, Netherlands
Percentage change from baseline in the Microvascular Health Index in the fasting mimicking diet or food supplement group compared to the placebo group
Time frame: 3 months
Percentage change from baseline in Urine albumin-to-creatinine ratio (UACR) in the fasting mimicking diet or food supplement group compared to the placebo
Time frame: 3 months
Percentage change from baseline in urinary heparanase levels in the fasting mimicking diet or food supplement group compared to the placebo
Time frame: 3 months
Percentage change from baseline in urinary MCP-1 levels in the fasting mimicking diet or food supplement group compared to the placebo
Time frame: 3 months
Percentage change from baseline in specific urinary heparan sulfate domains in the fasting mimicking diet or food supplement group compared to the placebo
Time frame: 3 months
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