This study evaluated efficacy of iodized salt for mothers and their six-month-old infants' thyroid hormones and visual information processing. Half of the participants received 450 g iodized salt for the household each week, while the other half received 225 ug iodine daily as a potassium iodide capsule.
Iodine is essential for the synthesis of thyroid hormones, and thyroid hormones regulate the metabolic processes of most cells and play important roles in human growth and development. Iodine deficiency disorders can have serious consequences on brain and physical development. In neonates iodine deficiency and hence insufficient supply of thyroid hormones could cause neonatal goiter, neonatal hypothyroidism, and endemic mental retardation. Iodine deficiency disorders can be prevented and controlled by providing iodine and iodine can be provided in different ways. However, the United Nations Children's Fund and the World Health Organization jointly recommended salt iodization where iodized salt is accessible. Iodized salt is a safe, cost effective and sustainable strategy to ensure sufficient intake of iodine by all individuals and to improve maternal and infant health. However, although the effect of iodine on human health is well established efficacy of iodized salt has not been studied.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
106
225 µg of iodine daily as a capsule of potassium iodide
450 g iodized salt provided for the household weekly. Salt iodine content was 30 to 40 mg iodine /kg salt as KIO3
Hawassa University
Awasa, Ethiopia
Change from baseline breast milk iodine concentration (µg/L) at six months
Laboratory analysis
Time frame: First week after delivery and at six months
Change from baseline urinary iodine concentration (µg/L at six months
Laboratory analysis
Time frame: First week after delivery and at six months
Change from baseline Infants' anthropometric measurement (Z-score) at six months
Measurement
Time frame: First week after delivery and at six months
Change from baseline thyroid hormones status at six months
Laboratory analysis
Time frame: First week after delivery and at six months
Infants' visual information processing
Looking behavior test
Time frame: At six months after delivery
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