Optical Coherence Tomography of Nerve Fiber Layer and Ganglion Cell Complex After Cataract Extraction

Kasr El Aini Hospital48 enrolled

Overview

Optical coherence tomography (OCT) for retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) is done before and after cataract extraction in patients with or without primary open angle glaucoma (POAG)

The investigator's study includes two groups of patients, each consists of 25 eyes, group 1 (cataract group)includes patients who are planned for cataract extraction without any other preexisting retinal or optic nerve pathology that may affect the RNFL thickness, while group 2 (combined cataract and glaucoma group) includes patients who are diagnosed with POAG controlled on medical treatment with cataract and planned for cataract extraction only. The OCT scans with complete ophthalmological examination are done before surgery and 6 weeks after uneventful cataract extraction (phacoemulsification with intraocular lens implantation)

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cataract Primary Open-angle Glaucoma

Interventions

Oct scansDIAGNOSTIC_TEST

Oct scans to assess thickness of RNFL and GCC before and after cataract extraction surgery in both groups

Eligibility

Sex: ALLMin age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: • patients with cataract without any other concomitant retinal, optic nerve head pathology other than POAG are included in the study and divided onto two groups Exclusion Criteria: * Patients having any retinal or optic nerve pathology that might have affected nerve fiber layer thickness other than POAG eg: high myopia * POAG patients who are planned for combined surgery * Refractive errors greater than spherical equivalent of 6 diopters (myopia or hypermetropia) * Dense cataract hindering OCT imaging * History of previous ocular surgery or trauma

Locations (1)

Kasr Al-Ainy teaching hospital

Cairo, Egypt

Outcomes

Primary Outcomes

RNFL and GCC thickness

Assessment of RNFL and GCC thickness change after cataract extraction

Time frame: Oct scans before and 6 weeks after surgery

Secondary Outcomes

Final best corrected visual acuity (BCVA)

Assessment of the final BCVA recorded according to the Snellen chart and converted to logMAR for statistical analysis

Time frame: Six weeks after cataract surgery

Data from ClinicalTrials.gov

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