In this study, cardiopulmonary exercise will be assessed to characterize the relevance of severity of COPD and coexisting cardiovascular comorbidities for exercise capacity.
In patients with chronic obstructive pulmonary disease (COPD) the interpretation of dyspnoea also needs to consider coexisting cardiovascular disease. Cardiopulmonary exercise testing (CPET) is used to characterize pulmonary and cardiac function and limitations during exercise. The investigators hypothesise that cardiopulmonary exercise is reduced in COPD patients with coexisting cardiovascular disease as well as in more symptomatic patients and in patients with frequent exacerbations. For this purpose, 100 patients with with stable COPD are characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing.
Study Type
OBSERVATIONAL
Enrollment
100
Measurement of lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing
University Hospital Düsseldorf, Division of Cardiology, Pulmonary Disease and Vascular Medicine
Düsseldorf, Germany
RECRUITINGMeasurement of oxygen uptake during cardiopulmonary exercise testing (% predicted)
Time frame: Baseline
measurement of dyspnoea quantified by the COPD assessment test as well as the modified Medical Research Council Scale
For the assessment of the symptoms of the study group and its relation to exercise capacity dyspnoea is assessed by accepted questionnaires typically used for COPD patients at baseline
Time frame: Baseline
Measurement of FEV1
Time frame: Baseline
Measurement the capillary pO2 in mmHg and capillary pCO2 at baseline
The blood gases pO2 and pCO2 are taken from the hyperaemic ear lobe to characterize the gas exchange during cardiopulmonary exercise which is a routine procedure
Time frame: Baseline
N-terminal pro brain natriuretic peptid (NTproBNP) in ng/L from peripheral venous blood at baseline
NTproBNP is analysed from peripheral venous blood to characterize potential heart failure and its relation to exercise capacity of the study subjects
Time frame: Baseline
Measurement of Maximum wattage during cardiopulmonary exercise testing
Time frame: Baseline
Measurement of Breathing reserve during cardiopulmonary exercise testing
BThe breathing reserve in % is assessed at the end of the cardiopulmonary exercise testing to characterize a ventilatory limitation of the exercise test. It is calculated as percent from the minute ventilation in relation to the maximum mandatory ventilation. The measurement is a routine measurement during cardiopulmonary exercise testing.
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Time frame: Baseline
Measurement of Oxygen pulse during cardiopulmonary exercise testing
Time frame: Baseline
Presence of cardiovascular comorbidities
For the cardiopulmonary characterization clinical characteristics, lung function, blood gases, laboratory investigation, ECG and echocardiography were used in addition to cardiopulmonary exercise testing.
Time frame: Baseline