The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia

Cairo University100 enrolled

Overview

100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index \[RI\], pulsatility index \[PI\] and systolic/diastolic \[S/D\] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Preeclampsia

Interventions

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Singleton pregnancy. * Primigravida or Multigravida. * Pregnant females ≥ 37 weeks of gestation. * Diagnosed as severe preeclampsia by the following criteria: * Sustained systolic blood pressure of ≥160 mmHg or a sustained diastolic blood pressure of ≥ 110 mmHg. * Proteinuria measured as +1 or more by dipstick or 24 hours urine collection with proteinuria ≥ 0.3 grams. * Oliguria or creatinine \> 1.1 mg%. * Laboratory findings characteristic of HELLP syndrome. * Symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision, epigastric pain. Exclusion Criteria: * Multifetal pregnancy. * History of epilepsy. * Patients with diabetes. * Patients with renal disease. * Fetuses with congenital anomalies. * Patients receiving anticoagulants e.g. heparin (unfractionated or low molecular weight). * Patients with severe IUGR. * Patients with accidental hemorrhage.

The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts