To optimize the perioperative management of patients undergoing laparoscopic radical cystectomy(LPC) for bladder cancer through observation of perioperative changes of Brain Natriuretic Peptide(BNP), stroke volume variation(SVV), central venous pressure(CVP) and the use of transthoracic echocardiography(TTE).
Long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer influence perioperative circulatory function, resulting in a series of pathophysiological changes. BNP is of high sensitivity and specificity in the evaluation of cardiac function. SVV and CVP are dynamic and static indices to predict fluid responsiveness. TTE is a good indicator of volume and cardiac function.Thus, we conducted the trial to assess the perioperative circulatory function in patients undergoing LPC. We hypothesized that long term pneumoperitoneum and steep trendelenburg in LPC for bladder cancer would increase perioperative blood volume and influence cardiac function.
Study Type
OBSERVATIONAL
Enrollment
186
Renji Hospital, School of Medicine, Shanghai Jiaotong University, China
Shanghai, Shanghai Municipality, China
Brain Natriuretic Peptide(BNP)
To observe the change of BNP perioperatively.
Time frame: before induction (T1), at the end of operation(T2), at 12 hours (T3) and 24 hours (T4) postoperatively
Central Venous Pressure(CVP)
To observe the change of CVP perioperatively.
Time frame: before induction (T1),at the end of operation (T2), at 12 hours (T3) and 24 hours (T4) postoperatively
Stroke Volume Variation(SVV)
To observe the change of SVV perioperatively.
Time frame: before induction (T1), at the end of operation (T2)
Transthoracic Echocardiography
To observe the change of End-diastolic volume(EDV) perioperatively
Time frame: before induction (T1),at the end of operation (T2), at 12 hours (T3) and 24 hours (T4) postoperatively
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