The Conveyor Study

Inclusion Criteria: 1. Subject is able and willing to comply with all assessments in the study. 2. Subject or subjects' legal representative have been informed of the nature of the study, agrees to participate, and has signed the approved consent form. 3. Age of Subject is ≥18. 4. Estimated life expectancy \>6 months. 5. Patients demonstrated to have symptomatic post-therapeutic mitral valve dysfunction as determined at diagnostic cardiac catheterization, echocardiography, and/or MR and a mitral valve annulus suitable for a "valve in valve" transcatheter valve replacement procedure using the Edwards SAPIEN 3™ TAVR device based on diagnostic cardiac catheterization, echocardiography and/or MR imaging. 6. Patient has been evaluated by a Heart Team and judged to be a candidate for mitral valve in valve procedure. 7. Patient has femoral and iliac artery dimensions sufficient to accept the study device (\>6 mm). 8. Patient is potential surgical candidate. Exclusion Criteria: 1. Patients with any clinical presentation that will exclude them from receiving a Edwards SAPIEN 3™ percutaneous valve. 2. Patients with vascular disease that would preclude navigation of the Conveyor System. 3. Patients who do not desire to participate in the study. 4. Patients who are judged to be mentally incapable of fully understanding the risks or potential benefits of participation in the study. 5. Patients with visible thrombus in the left atrium or on the mitral valve apparatus/replacement. 6. Patient requires urgent or emergent treatment. 7. Patient has significant aortic valve disease or previous aortic valve replacement. 8. Pregnant patients (must have negative pregnancy test).