Apply CT angiography, CT perfusion imaging and advanced image processing techniques to improve revascularization decision-making and surgical strategies in patients undergoing coronary artery bypass graft surgery.
The objective of this study is to integrate noninvasively acquired anatomical and functional information to develop clinically applicable tools for meaningful per-vessel revascularization decisions. The decisions will be based on quantitative lesion-specific ischemia and viability and flow simulations. These will be based on CT anatomy enhanced with a function for prediction of hemodynamic improvement after CABG. Aim 1: Predict restoration of myocardial perfusion from coronary artery bypass graft surgery. The investigators will perform cardiac CT before and after CABG and measure absolute changes in myocardial perfusion as the functional outcome of CABG. The investigators will investigate clinical, surgical and imaging variables in association with post-CABG perfusion improvement on a per-vessel and per-patient level. Aim 2: Non-invasively quantify vessel-specific ischemia for meaningful CABG decisions. The investigators will develop and validate tools for assessment of vessel-specific ischemia and viability. The investigators will assess the potential impact of CT guided CABG by comparing the per-vessel need for grafting with standard care. Aim 3: Predict CABG benefit through multi-parameter flow simulations Hypothesis: Integration of myocardial perfusion and viability can improve flow simulation models to predict CABG outcome. The investigators will develop new computational fluid dynamics models enriched with functional parameters and explore the potential of virtual grafting to improve hemodynamic outcomes.
Study Type
OBSERVATIONAL
Enrollment
200
Palo Alto Veterans Affaird Healthcare System
Palo Alto, California, United States
Stanford University
Palo Alto, California, United States
University of California San Diego
San Diego, California, United States
Change in myocardial blood flow from baseline measured by cardiac CT
Myocardial blood flow will be measured by dynamic stress CT perfusion imaging before and 2 months after CABG. The primary endpoint is the difference MBF values between both examinations, per coronary distribution.
Time frame: 2 Months
Bypass graft obstruction by cardiac CT
The presence of bypass grafts obstruction will be assessed on CT angiography
Time frame: 2 Months
Change in angina pectoris assessed by SAQ
Severity of anginal complaints will be assessed using the Seattle Angina Questionnaire before and 1 year after CABG.
Time frame: 1 Year
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